Tcf21 modulates fibroblast activation and promotes cardiac fibrosis after injury via Pdgfrb signaling

Abstract excerpt

Transformation of cardiac fibroblasts into matrix-producing myofibroblasts plays an important role in tissue repair and fibrosis after myocardial injury. Tcf21 is a basic helix-loop-helix transcription factor that is essential for the development of cardiac fibroblasts and the epicardium. Myofibroblasts are derived from Tcf21 (+) residual fibroblasts; however, whether Tcf21 itself promotes fibrosis is still...

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