Article
From genotypes of immunoglobulin constant heavy G chains (Fcγ) (GM) genes (IGHG) to phenotypes in childhood asthma.
International archives of allergy and immunology - 1 Jan 2012
Oxelius Vivi-Anne
Abstract excerpt
BACKGROUND: IgE-mediated allergy is associated with immunoglobulin heavy constant G chain (Fcγ) (GM) genes (IGHG) on chromosome 14q32.3. Investigation of the alternative GM allotypes of γ3, γ1 and γ2 chains has disclosed new structural and functional IgG subclasses and B-cell variants, with possible effects on childhood asthma. OBJECTIVE: To investigate different IGHG (GM) gene complexes in a childhood asthma...
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