Article
Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2006
Oxelius V-A, Bråbäck L, Ahlstedt S, Björkstén B
Abstract excerpt
BACKGROUND: Several candidate genes have been found to be associated with the inflammatory response of IgE-mediated allergy, so also the immunoglobulin constant heavy G chain (IGHG) genes. The IGHG genes are situated close to the IGHE gene on chromosome 14q32, 5'mu, delta, gamma3, gamma1, alpha1, gamma2, gamma4, epsilon, alpha2, 3'. They are inherited in a Mendelian fashion and expressed randomly in allelic...
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