Article
Restricted immunoglobulin constant heavy G chain genes in primary immunodeficiencies.
Clinical immunology (Orlando, Fla.) - 1 Aug 2008
Oxelius Vivi-Anne, Ochs Hans D, Hammarström Lennart
Abstract excerpt
Some primary immunodeficiencies (PIDs) express low serum levels of antibodies. The constant heavy G chain (IGHG) genes, also representing Fc domains of gamma 3, gamma 1 and gamma 2 on chromosome 14q32.3, genotyped by the alternative IgG subclass allotypes, found in four fixed IGHG haplotypes, designating four B cell variants, were identified by a competitive ELISA and double immunodiffusion. IGHG genes were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
