Article
Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the Elm1 kinase to the bud neck.
PLoS genetics - 1 Jan 2012
Merlini Laura, Fraschini Roberta, Boettcher Barbara, Barral Yves, Lucchini Giovanna, Piatti Simonetta
Abstract excerpt
The first step towards cytokinesis in budding yeast is the assembly of a septin ring at the future site of bud emergence. Integrity of this ring is crucial for cytokinesis, proper spindle positioning, and the spindle position checkpoint (SPOC). This checkpoint delays mitotic exit and cytokinesis as long as the anaphase spindle does not properly align with the division axis. SPOC signalling requires the Kin4...
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