Article
Emerging effects of early environmental factors over genetic background for type 1 diabetes susceptibility: evidence from a Nationwide Italian Twin Study.
The Journal of clinical endocrinology and metabolism - 1 Aug 2012
Nisticò Lorenza, Iafusco Dario, Galderisi Alfonso, Fagnani Corrado, Cotichini Rodolfo, Toccaceli Virgilia, Stazi Maria Antonietta
Abstract excerpt
CONTEXT: The incidence of type 1 diabetes has been increasing over time. OBJECTIVE: We estimated the genetic and environmental components of type 1 diabetes susceptibility in a twin cohort of recent-onset cases to explore the sources of changing disease epidemiology. DESIGN: We linked the population-based Italian Twin Registry with 14803 type 1 diabetes records from 36 pediatric diabetes care centers throughout...
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