Article
Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study.
Diabetologia - 1 Jul 2010
Lehtovirta M, Pietiläinen K H, Levälahti E, Heikkilä K, Groop L, Silventoinen K, Koskenvuo M, Kaprio J
Abstract excerpt
AIMS/HYPOTHESIS: We investigated whether BMI predicts type 2 diabetes in twins and to what extent that is explained by common genetic factors. METHODS: This was a population-based twin cohort study. Monozygotic (n = 4,076) and dizygotic (n = 9,109) non-diabetic twin pairs born before 1958 answered a questionnaire in 1975, from which BMI was obtained. Information on incident cases of diabetes was obtained by...
Topics
- Adult
- Body Mass Index
- Cohort Studies
- Diabetes Mellitus, Type 2
- Female
- Finland
- Genetic Variation
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Twins, Dizygotic
- Twins, Monozygotic