Article
MALDI-TOF mass spectrometry screening of cholelithiasis risk markers in the gene of HNF1alpha.
Journal of proteomics - 27 Jun 2012
Richter Dominique, Harsch Simone, Strohmeyer André, Hirobe-Jahn Satoko, Schimmel Silke, Renner Olga, Müller Oliver, Schäffeler Elke, Kratzer Wolfgang, Schwab Matthias, Stange Eduard F
Abstract excerpt
In recent years MALDI-TOF MS gained importance for high-throughput DNA analysis. In the present study this technique was used for the pathogenetic analysis of gallstone disease. The intestinal apical sodium-dependent bile acid transporter (ASBT) shows a genetic association with gallstone disease. ASBT has 3 binding sites in its 5'UTR for hepatocyte nuclear factor 1alpha (HNF1alpha). We hypothesized that genetic...
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