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Article

Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss.

Brain pathology (Zurich, Switzerland) - 1 Nov 2012

Kim Young-Ho, Nonoguchi Naosuke, Paulus Werner, Brokinkel Benjamin, Keyvani Kathy, Sure Ulrich, Wrede Karsten, Mariani Luigi, Giangaspero Felice, Tanaka Yuko, Nakazato Yoichi, Vital Anne, Mittelbronn Michel, Perry Arie, Ohgaki Hiroko

Abstract excerpt

Chromosomal 7q34 duplication and BRAF-KIAA1549 fusion is a characteristic genetic alteration in pilocytic astrocytomas. 7q34 gain appears to be common in diffuse astrocytomas, but its significance is unclear. We assessed BRAF gain and BRAF mutations in 123 low-grade diffuse gliomas, including 55 diffuse astrocytomas, 18 oligoastrocytomas and 50 oligodendrogliomas. Quantitative polymerase chain reaction (PCR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22568401
DOI: 10.1111/j.1750-3639.2012.00601.x
PMCID: PMC8057626

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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