Article
Familial predisposition to alcoholic liver disease: a case-control study.
European journal of gastroenterology & hepatology - 1 Jul 2012
Ali Ala K, Jones Jayne S, Bradley Martin P, Bhala Neeraj, Rahman Arifur, Peck Robert J, Teare Dawn M, Gleeson Dermot
Abstract excerpt
OBJECTIVES: The variable susceptibility to alcoholic liver disease (ALD) may be genetic in origin, but clear candidate genes have not yet emerged. This study aimed to assess familial clustering of ALD using a case-control strategy. METHODS: We recruited two cohorts of heavy drinkers (>60 U/week for men or >40 U/week for women): 291 individuals with decompensated ALD (Child's grade B or C) and 208 controls with...
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