Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.

doi:10.1016/s1383-5742(00)00018-1

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Article

Molecular epidemiology of breast cancer: genetic variation in steroid hormone metabolism.

Mutation research - 1 Apr 2000

Kristensen V N, Borresen-Dale A L

Abstract excerpt

The age-specific incidence rate of breast cancer in women rises until menopause, levels off and then rises again at a much lower rate indicating a possible hormonal influence on the disease risk. A large amount of evidence has implicated hormones and other compounds with oestrogen activity in the pathogenesis of certain endocrine cancers, particularly breast cancer. Widely dispersed hormone-like chemicals,...

Topics

17-Hydroxysteroid Dehydrogenases
Arylsulfatases
Breast Neoplasms
Cytochrome P-450 Enzyme System
Estrogens
Female
Genetic Variation
Humans
Molecular Epidemiology
Polymorphism, Genetic
Steryl-Sulfatase

Source

Open in PubMed

Identifiers

PMID: 10767642
DOI: 10.1016/s1383-5742(00)00018-1

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