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Article

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.

Human molecular genetics - 15 Jul 2009

Sanna Serena, Busonero Fabio, Maschio Andrea, McArdle Patrick F, Usala Gianluca, Dei Mariano, Lai Sandra, Mulas Antonella, Piras Maria Grazia, Perseu Lucia, Masala Marco, Marongiu Mara, Crisponi Laura, Naitza Silvia, Galanello Renzo, Abecasis Gonçalo R, Shuldiner Alan R, Schlessinger David, Cao Antonio, Uda Manuela

Abstract excerpt

Bilirubin, resulting largely from the turnover of hemoglobin, is found in the plasma in two main forms: unconjugated or conjugated with glucuronic acid. Unconjugated bilirubin is transported into hepatocytes. There, it is glucuronidated by UGT1A1 and secreted into the bile canaliculi. We report a genome wide association scan in 4300 Sardinian individuals for total serum bilirubin levels. In addition to the two...

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Identifiers

PMID: 19419973
DOI: 10.1093/hmg/ddp203
PMCID: PMC2701337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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