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Article

Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo.

The Journal of biological chemistry - 2 Oct 2009

Chamberland Angela, Wang Eunice, Jones Aled R, Collins-Racie Lisa A, LaVallie Edward R, Huang Ying, Liu Lin, Morris Elisabeth A, Flannery Carl R, Yang Zhiyong

Abstract excerpt

Mass spectrometry-based proteomic analyses performed on cartilage tissue extracts identified the serine protease HtrA1/PRSS11 as a major protein component of human articular cartilage, with elevated levels occurring in association with osteoarthritis. Overexpression of a catalytically active form...

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Identifiers

PMID: 19657146
DOI: 10.1074/jbc.M109.037051
PMCID: PMC2785663

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19657146-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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