Article
Selection of an M184V mutation in the cerebrospinal fluid of a treatment-naive HIV-infected individual starting darunavir-based therapy.
Antiviral therapy - 1 Jan 2011
Cornelissen Marion, Back Nicole K T, Burger David M, Blom Petra, Portegies Peter, Prins Jan M, van der Valk Marc
Abstract excerpt
Here, we describe a newly diagnosed HIV-1-infected patient, in whom shortly after the initiation of a darunavir-based regimen, the HIV-1 virus exclusively mutated in the cerebrospinal fluid (CSF), leading to an increase in CSF HIV-1 RNA load and neurological complaints.
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