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Article

Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index.

British journal of clinical pharmacology - 1 Jan 2013

Jiang Fen, Desta Zeruesenay, Shon Ji-Hong, Yeo Chang-Woo, Kim Ho-Sook, Liu Kwang-Hyeon, Bae Soo-Kyung, Lee Sang-Seop, Flockhart David A, Shin Jae-Gook

Abstract excerpt

AIMS: To evaluate the effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites in relation to the CYP2B6*6 genotype and explore potential phenotyping indices for CYP2B6 activity in vivo using a low dose of oral efavirenz. METHODS: We conducted a randomized three phase crossover study in 17 healthy Korean subjects pre-genotyped for the CYP2B6*6 allele (CYP2B6*1/*1, n =...

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Identifiers

PMID: 22554354
DOI: 10.1111/j.1365-2125.2012.04314.x
PMCID: PMC3555064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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