Disruption of protein quality control in Parkinson's disease.

doi:10.1101/cshperspect.a009423

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Article

Disruption of protein quality control in Parkinson's disease.

Cold Spring Harbor perspectives in medicine - 1 May 2012

Cook Casey, Stetler Caroline, Petrucelli Leonard

Abstract excerpt

Parkinson's disease (PD), like a number of neurodegenerative diseases associated with aging, is characterized by the abnormal accumulation of protein in a specific subset of neurons. Although researchers have recently elucidated the genetic causes of PD, much remains unknown about what causes increased protein deposition in the disease. Given that increased protein aggregation may result not only from an increase...

Topics

Adenosine Triphosphatases
Aging
Animals
Autophagy
Environmental Pollutants
Humans
Lysosomes
Mice
Mutation
Oxidative Stress
Parkinson Disease
Proteasome Endopeptidase Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Folding

Proteins

Proteolysis

Proteostasis Deficiencies

Rats

Risk Factors

Source

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Identifiers

PMID: 22553500
DOI: 10.1101/cshperspect.a009423
PMCID: PMC3331692

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