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Article

Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation.

International journal of cancer - 1 Jan 2008

Ahmed Mansoor M, Sheldon David, Fruitwala Mushtaq A, Venkatasubbarao Kolaparthi, Lee Eun Y, Gupta Seema, Wood Craig, Mohiuddin Mohammed, Strodel William E

Abstract excerpt

Oncogenic ras is known to inhibit cell death and growth inhibitory genes and activate prosurvival genes. Proapoptotic gene PAR-4, has been found to be downregulated by oncogenic ras. Since pancreatic tumors harbor a high incidence of K-ras point mutations, we hypothesized that oncogenic K-ras might influence the function and expression of PAR-4. PAR-4 expression levels were analyzed in 4 established pancreatic...

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Share to Adenocarcinoma
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, ras

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Source

Identifiers

PMID: 17893871
DOI: 10.1002/ijc.23019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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