Article
In vivo selection of a population of Trypanosoma cruzi and clones resistant to benznidazole.
Parasitology - 1 Feb 1998
Murta S M, Romanha A J
Abstract excerpt
A benznidazole-resistant population of Trypanosoma cruzi, Y strain, was selected after 25 successive passages (8 months) in mice treated with a single high drug dose. Initially, the resistant parasites produced a low parasitaemia level and low mortality rate in infected mice. Thereafter, the para...
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