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Article

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole.

Memorias do Instituto Oswaldo Cruz - 1 May 2015

Zingales Bianca, Araujo Rafael Gomes Aquino, Moreno Margoth, Franco Jaques, Aguiar Pedro Henrique Nascimento, Nunes Solange Lessa, Silva Marcelo Nunes, Ienne Susan, Machado Carlos Renato, Brandão Adeilton

Abstract excerpt

Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety...

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Identifiers

PMID: 25946152
DOI: 10.1590/0074-02760140407
PMCID: PMC4489481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25946152-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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