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Article

Role of the USF1 transcription factor in diabetic kidney disease.

American journal of physiology. Renal physiology - 1 Aug 2011

Sanchez Amber P, Zhao JingHong, You Young, Declèves Anne-Emilie, Diamond-Stanic Maggie, Sharma Kumar

Abstract excerpt

The predominant transcription factors regulating key genes in diabetic kidney disease have not been established. The transcription factor upstream stimulatory factor 1 (USF1) is an important regulator of glucose-mediated transforming growth factor (TGF)-β1 expression in mesangial cells; however, its role in the development of diabetic kidney disease has not been evaluated. In the present study, wild-type (WT;...

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Identifiers

PMID: 21543418
DOI: 10.1152/ajprenal.00221.2011
PMCID: PMC3154594

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