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Article

Cis and trans regulation of hepcidin expression by upstream stimulatory factor.

Blood - 15 Dec 2006

Bayele Henry K, McArdle Harry, Srai Surjit K S

Abstract excerpt

Hepcidin is the presumed negative regulator of systemic iron levels; its expression is induced in iron overload, infection, and inflammation, and by cytokines, but is suppressed in hypoxia and anemia. Although the gene is exquisitely sensitive to changes in iron status in vivo, its mRNA is devoid of prototypical iron-response elements, and it is therefore not obvious how it may be regulated by iron flux. The...

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Identifiers

PMID: 16902156
DOI: 10.1182/blood-2005-07-027037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Cis and trans regulation of hepcidin expression by upstream stimulatory factor.PMID 16902156Read ↗

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Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase.Semantic proximity Read ↗

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsivenessSemantic proximity Read ↗

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