Chronic complication risk and benefits of fenofibrate in type 2 diabetes by a PPARα polymorphism (rs6008845, C/T): a FIELD trial substudy.

doi:10.1016/j.diabres.2026.113168

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Chronic complication risk and benefits of fenofibrate in type 2 diabetes by a PPARα polymorphism (rs6008845, C/T): a FIELD trial substudy.

Diabetes research and clinical practice - 1 Apr 2026

Januszewski Andrzej S, Huang Michael L H, Mangani Abubakar Siddiq, Ong Kwok Leung, Dalton Chris, O'Connell Rachel L, Li Liping, Sullivan David R, Strbenac Dario, Donoghoe Mark W, Brown Christopher, Carroll Luke M, Gebski Val, Scott Russell S, John Simes R, Jenkins Alicia J, Keech Anthony C

Abstract excerpt

OBJECTIVE: Peroxisome proliferator-activated receptor α (PPARα) regulates lipid metabolism, cardiac energy balance, vascular inflammation and cell differentiation. We examined whether a PPARα gene variant (rs6008845, C/T) is associated with risk of chronic complications and death, and with benefit of fenofibrate (a PPARα agonist) in adults with type 2 diabetes. METHODS: The variant was genotyped in 8,159...

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PMID: 41730506
DOI: 10.1016/j.diabres.2026.113168

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