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Glutathione deficiency in type 2 diabetes impairs cytokine responses and control of intracellular bacteria

1 May 2012

Abstract excerpt

Individuals with type 2 diabetes are at increased risk of acquiring melioidosis, a disease caused by Burkholderia pseudomallei infection. Although up to half of melioidosis patients have underlying diabetes, the mechanisms involved in this increased susceptibility are unknown. We found that B. pseudomallei-infected PBMCs from diabetic patients were impaired in IL-12p70 production, which resulted in decreased...

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PMID: 22546856
DOI: 10.1172/jci57817

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