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Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents

15 May 2014

Abstract excerpt

Hepatitis C virus (HCV) is transmitted between hepatocytes via classical cell entry but also uses direct cell-cell transfer to infect neighboring hepatocytes. Viral cell-cell transmission has been shown to play an important role in viral persistence allowing evasion from neutralizing antibodies. In contrast, the role of HCV cell-cell transmission for antiviral resistance is unknown. Aiming to address this...

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PMID: 24830295
DOI: 10.1371/journal.ppat.1004128

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