Article
Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to α-melanocyte-stimulating hormone (α-MSH).
The Journal of biological chemistry - 22 Jun 2012
McDaniel Faith K, Molden Brent M, Mohammad Sameer, Baldini Giovanna, McPike Lakisha, Narducci Paola, Granell Susana, Baldini Giulia
Abstract excerpt
Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in the hypothalamus where it controls feeding behavior. MC4R cycles constitutively and is internalized at the same rate in the presence or absence of stimulation by the agonist, melanocyte-stimulating hormone (α-MSH). This is different from other G-protein-coupled receptors, such as β(2)-adrenergic receptor (β(2)AR), which internalizes more...
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