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Article

Constitutive activity in melanocortin-4 receptor: biased signaling of inverse agonists.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2014

Tao Ya-Xiong

Abstract excerpt

The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeostasis, including both energy intake and energy expenditure. It mediates the actions of a number of hormones on energy balance. The endogenous ligands for MC4R include peptide agonists derived from processing of proopiomelanocortin and the antagonist Agouti-related peptide (AgRP). Wild-type MC4R has some basal (constitutive) activity....

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Share to Extracellular Signal-Regulated MAP Kinases
Share to GTP-Binding Protein alpha Subunits, Gs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melanocortin, Type 4

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Source

Identifiers

PMID: 24931195
DOI: 10.1016/B978-0-12-417197-8.00005-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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