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Article

Constitutive receptor activity series: endogenous inverse agonists and constitutive receptor activity in the melanocortin system.

Trends in pharmacological sciences - 1 Apr 2006

Adan Roger A H

Abstract excerpt

The recent discovery of melanocortin receptor mutations that selectively decrease constitutive receptor activity in obese individuals supports the physiological relevance of constitutive melanocortin receptor activity and its control by an endogenous inverse agonist. Furthermore, studies using mice that lack endogenous melanocortin receptor agonists show that differences in coat color are caused by different...

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Identifiers

PMID: 16500715
DOI: 10.1016/j.tips.2006.02.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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