Isolation and characterization of Bacillus stearothermophilus 30S and 50S ribosomal protein mutations.

Abstract excerpt

Bacillus stearothermophilus mutations which confer resistance to or dependence on a variety of ribosome-targeted antibiotics have been isolated. Many of these mutations produce ribosomal proteins with altered mobilities in a two-dimensional gel electrophoresis system. This collection of altered thermophilic ribosomal proteins will be useful in examining ribosomal structure and function.

Topics

• Bacterial Proteins
• Drug Resistance, Microbial
• Electrophoresis, Gel, Two-Dimensional
• Geobacillus stearothermophilus
• Mutation
• Protein Biosynthesis
• Ribosomal Proteins