Article
Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis.
Diabetologia - 1 Aug 2012
Islam M, Jafar T H, Wood A R, De Silva N M G, Caulfield M, Chaturvedi N, Frayling T M
Abstract excerpt
AIMS/HYPOTHESIS: Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs further study. We hypothesised that genetic variants associated with diabetes-related traits in Europeans would explain a similar proportion of phenotypic variance in a Pakistani population and could be used in Mendelian randomisation analyses. METHODS: We...
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