Article
The accuracy of aminoacylation--ensuring the fidelity of the genetic code.
Experientia - 1 Dec 1990
Söll D
Abstract excerpt
The fidelity of protein biosynthesis rests not only on the proper interaction of the messenger RNA codon with the anticodon of the tRNA, but also on the correct attachment of amino acids to their corresponding (cognate) transfer RNA (tRNA) species. This process is catalyzed by the aminoacyl-tRNA synthetases which discriminate with remarkable selectivity amongst many structurally similar tRNAs. The basis for this...
Topics
- Amino Acyl-tRNA Synthetases
- Base Sequence
- Escherichia coli
- Genes, Suppressor
- Genetic Code
- Molecular Sequence Data
- Mutation
- Protein Conformation
- RNA, Transfer, Gln
- Structure-Activity Relationship
- Transfer RNA Aminoacylation