Article
Variation of benzbromarone elimination in man--a population study.
European journal of clinical pharmacology - 1 Jan 1990
Walter-Sack I, Gresser U, Adjan M, Kamilli I, Ittensohn A, de Vries J X, Weber E, Zöllner N
Abstract excerpt
The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an appropriate procedure to determine the elimination phenotype. Based on this procedure, 148 of 153 healthy individuals...
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