Article
Pharmacokinetic parameters of bromperidol in Korean subjects.
Human psychopharmacology - 1 Aug 2006
Lee Soo-Youn, Kim Yoon Gyoon, Kim Hyung-Gun, Kim Jong-Won
Abstract excerpt
We have presented pharmacokinetic parameters of bromperidol (BP) in 14 healthy Korean subjects. Additionally, we have investigated the effects of dose and genetic polymorphisms on BP metabolism and on extrapyramidal symptoms (EPS). The T(max) (3.9 +/- 0.9 h), clearance (1.37 +/- 0.52 ml/h/kg), and t(1/2) (20.4 +/- 3.7 h) obtained in our study are comparable to those in previous Caucasian studies, although...
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