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Article

Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer.

European journal of endocrinology - 1 Jul 2012

Lee Jung Uee, Huang Songmei, Lee Min Hee, Lee Seong Eun, Ryu Min Jeong, Kim Soung Jung, Kim Yong Kyung, Kim Seul Young, Joung Kyong Hye, Kim Jin Man, Shong Minho, Jo Young Suk

Abstract excerpt

OBJECTIVE: The genetic mutations causing the constitutive activation of MEK/ERK have been regarded as an initiating factor in papillary thyroid carcinoma (PTC). The ERK-specific dual specificity phosphatase 6 (DUSP6) is part of the ERK-dependent transcriptional output. Therefore, the coordinated...

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Topics

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Share to Carcinoma, Papillary
Share to Neoplasm Invasiveness
Share to Phosphorylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Predictive Value of Tests

Share to Proliferating Cell Nuclear Antigen

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins c-fos

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 22535643
DOI: 10.1530/EJE-12-0010

Genes

DUSP6
BRAF
PCNA
FOS
MAPK3
MYC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22535643-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer.PMID 22535643Read ↗

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers.Semantic proximity Read ↗

Targeting DUSP5 suppresses malignant phenotypes of BRAF-mutant thyroid cancer cells and improves their response to sorafenib.Semantic proximity Read ↗

DNA methylation of MAPK signal-inhibiting genes in papillary thyroid carcinoma.Semantic proximity Read ↗

Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.Semantic proximity Read ↗

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasionSemantic proximity Read ↗

Expression of cancer-associated fibroblast-related proteins in thyroid papillary carcinoma.Semantic proximity Read ↗

PSD3 is an oncogene that promotes proliferation, migration, invasion, and G1/S transition while inhibits apoptotic in papillary thyroid cancerSemantic proximity Read ↗

Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinomaSemantic proximity Read ↗

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