Article
The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry.
Molecular biology of the cell - 1 Jun 2012
Gordón-Alonso Mónica, Rocha-Perugini Vera, Álvarez Susana, Moreno-Gonzalo Olga, Ursa Angeles, López-Martín Soraya, Izquierdo-Useros Nuria, Martínez-Picado Javier, Muñoz-Fernández Maria Ángeles, Yáñez-Mó María, Sánchez-Madrid Francisco
Abstract excerpt
Syntenin-1 is a cytosolic adaptor protein involved in several cellular processes requiring polarization. Human immunodeficiency virus type 1 (HIV-1) attachment to target CD4(+) T-cells induces polarization of the viral receptor and coreceptor, CD4/CXCR4, and cellular structures toward the virus contact area, and triggers local actin polymerization and phosphatidylinositol 4,5-bisphosphate (PIP(2)) production,...
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