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Article

HIV-1 gag recruits PACSIN2 to promote virus spreading.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2018

Popov Sergei, Popova Elena, Inoue Michio, Wu Yuanfei, Göttlinger Heinrich

Abstract excerpt

The p2b domain of Rous sarcoma virus (RSV) Gag and the p6 domain of HIV-1 Gag contain late assembly (L) domains that engage the ESCRT membrane fission machinery and are essential for virus release. We now show that the PPXY-type RSV L domain specifically recruits the BAR domain protein PACSIN2 into virus-like particles (VLP), in addition to the NEDD4-like ubiquitin ligase ITCH and ESCRT pathway components such as...

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Topics

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Share to Actin Cytoskeleton
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Protein Domains

Share to src Homology Domains

Share to Ubiquitin-Protein Ligases

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 29891700
DOI: 10.1073/pnas.1801849115
PMCID: PMC6142272

Genes

PACSIN2
NEDD4
ITCH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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