Article
Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy.
Alimentary pharmacology & therapeutics - 1 Sept 2007
Palmieri O, Latiano A, Bossa F, Vecchi M, D'Incà R, Guagnozzi D, Tonelli F, Cucchiara S, Valvano M R, Latiano T, Andriulli A, Annese V
Abstract excerpt
AIM: To evaluate the polymorphisms of several genes involved in the azathioprine and mercaptopurine metabolism, in an attempt to explain their toxicity and efficacy in Crohn's disease and ulcerative colitis. METHODS: In 422 consecutive patients (250 with Crohn's disease and 172 with ulcerative colitis) and 245 healthy controls, single nucleotide polymorphisms of thiopurine methyltransferase, inosine triphosphate...
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