Article
The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes.
Cardiovascular diabetology - 26 Apr 2012
Patel Sheila K, Wai Bryan, Macisaac Richard J, Grant Sharon, Velkoska Elena, Ord Michelle, Panagiotopoulos Sianna, Jerums George, Srivastava Piyush M, Burrell Louise M
Abstract excerpt
BACKGROUND: Connective tissue growth factor (CTGF) has been implicated in the cardiac and kidney complications of type 2 diabetes, and the CTGF -945 G/C polymorphism is associated with susceptibility to systemic sclerosis, a disease characterised by tissue fibrosis. This study investigated the association of the CTGF -945 G/C promoter variant with cardiac complications (left ventricular (LV) hypertrophy (LVH),...
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