Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes.

Journal of negative results in biomedicine - 8 May 2011

Dendooven Amélie, Nguyen Tri Q, Brosens Lodewijk, Li Dongxia, Tarnow Lise, Parving Hans-Henrik, Rossing Peter, Goldschmeding Roel

Abstract excerpt

The -945GC polymorphism (rs6918698) in the connective tissue growth factor gene promoter (CTGF/CCN-2) has been associated with end organ damage in systemic sclerosis. Because CTGF is important in progression of diabetic kidney disease, we investigated whether the -945GC polymorphism is associated with plasma CTGF level and outcome in type 1 diabetes. The study cohort consisted of 448 diabetic nephropathy patients...

Topics

Join the communities discussing this publication.

Cohort Studies
Connective Tissue Growth Factor
Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Diabetic Nephropathies

Disease Progression

Kidney Function Tests

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 21548990
DOI: 10.1186/1477-5751-10-4
PMCID: PMC3112427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CTGF -945GC polymorphism is not associated with plasma CTGF and does not predict nephropathy or outcome in type 1 diabetes.PMID 21548990Read ↗

The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes.Semantic proximity Read ↗

Interleukin-4 (IL4) -590C/T (rs2243250) gene polymorphism is not associated with diabetic nephropathy (DN) in Caucasians with type 2 diabetes mellitus (T2DM).Semantic proximity Read ↗

Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes.Semantic proximity Read ↗

A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy.Semantic proximity Read ↗

Resequencing of the characterised CTGF gene to identify novel or known variants, and analysis of their association with diabetic nephropathy.Semantic proximity Read ↗

Gene polymorphisms as clinical tools in chronic glomerulopathies: a prospective study.Semantic proximity Read ↗

CCN2 (CTGF) gene polymorphism is a novel prognostic risk factor for cardiovascular outcomes in hemodialysis patients.Semantic proximity Read ↗

Association between the CTGF -945C/G polymorphism and systemic sclerosis: a meta-analysis.Semantic proximity Read ↗

CNDP1 (CTG)5 allele and cardiovascular events in high-risk patients: LURIC study results.Semantic proximity Read ↗

TGF-beta 1 as a genetic susceptibility locus for advanced diabetic nephropathy in type 1 diabetes mellitus: an investigation of multiple known DNA sequence variants.Semantic proximity Read ↗

Correlation of CTGF gene promoter methylation with CTGF expression in type 2 diabetes mellitus with or without nephropathySemantic proximity Read ↗

Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.