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Article

Activating internal tandem duplication mutations of the fms-like tyrosine kinase-3 (FLT3-ITD) at complete response and relapse in patients with acute myeloid leukemia.

Haematologica - 1 Aug 2012

Nazha Aziz, Cortes Jorge, Faderl Stefan, Pierce Sherry, Daver Naval, Kadia Tapan, Borthakur Gautam, Luthra Raja, Kantarjian Hagop, Ravandi Farhad

Abstract excerpt

FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations are among the most frequent molecular aberrations in patients with acute myeloid leukemia. We retrospectively analyzed 324 patients with acute myeloid leukemia treated with front-line induction chemotherapy between October 2004 and March 2010. Fifty-six patients had FLT3-ITD mutation at diagnosis. Fifty-one (91%) patients with FLT3-ITD...

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Source

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Identifiers

PMID: 22532519
DOI: 10.3324/haematol.2012.062638
PMCID: PMC3409823

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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