Article
Stability and prognostic influence of FLT3 mutations in paired initial and relapsed AML samples.
Leukemia - 1 Jul 2006
Cloos J, Goemans B F, Hess C J, van Oostveen J W, Waisfisz Q, Corthals S, de Lange D, Boeckx N, Hählen K, Reinhardt D, Creutzig U, Schuurhuis G J, Zwaan Ch M, Kaspers G J L
Abstract excerpt
In acute myeloid leukemia (AML), activating mutations in the fms-like tyrosine kinase 3 (FLT3) gene predict poor prognosis. We determined FLT3 internal tandem duplications (FLT3/ITD) and D835 point mutations in paired initial and relapse samples from 80 pediatric and adult AML patients. One D835 point mutation was found in an initial pediatric AML sample. Fms-like tyrosine kinase 3/ITDs were present in 21 initial...
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