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Article

Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines

27 Feb 2004

Abstract excerpt

Over 80% of patients with advanced metastatic testis tumors can be cured using cisplatin-based combination chemotherapy. This is unusual as metastatic cancer in adults is usually incurable. Cell lines derived from testis tumors retain sensitivity to cisplatin in vitro. We previously investigated 2 testis tumor cell lines with a low capacity to remove cisplatin-induced DNA damage and found that they had low levels...

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Identifiers

PMID: 15095299
DOI: 10.1002/ijc.20134

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Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell linesPMID 15095299Read ↗

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Defects in interstrand cross-link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin.Semantic proximity Read ↗

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