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Article

Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV radiation

31 Jan 2008

Abstract excerpt

Most testicular germ cell tumors are curable using cisplatin-based chemotherapy, and cell lines from these tumors are unusually sensitive to cisplatin and other DNA-damaging agents. It has been suggested that this might be caused by a lower-than normal nucleotide excision repair (NER) activity. Previous studies found that cell lines from testicular germ cell tumors have on average about one-third the level of the...

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PMID: 18240296
DOI: 10.1002/mc.20418

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Elevation of XPA protein level in testis tumor cells without increasing resistance to cisplatin or UV radiationPMID 18240296Read ↗

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