Article
Tumor suppression by collagen XV is independent of the restin domain.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jun 2012
Mutolo Michael J, Morris Kirsten J, Leir Shih-Hsing, Caffrey Thomas C, Lewandowska Marzena A, Hollingsworth Michael A, Harris Ann
Abstract excerpt
Non-fibrillar collagen XV is a chondroitin sulfate modified glycoprotein that is associated with the basement membrane zone in many tissues. Its precise functions remain to be fully elucidated though it clearly plays a critical role in the structural integrity of the extracellular matrix. Loss of collagen XV from the basement membrane zone precedes invasion of a number of tumor types and we previously showed that...
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