Article
Alterations of Collagen XVII Expression During Transformation of Oral Epithelium to Dysplasia and Carcinoma
1 Jul 2003
Abstract excerpt
Collagen XVII (BP180) is a hemidesmosomal transmembrane component that has been hypothesized to participate in keratinocyte adhesion and motility. Using immunohistochemical (IHC) and in situ hybridization (ISH) methods, we showed downregulation of collagen XVII in basal cells in mild dysplasias and upregulation in suprabasal keratinocytes in moderate and severe dysplasias as well as in the central cells of grade...
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