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Article

The derived allele of ASPM is associated with lexical tone perception.

PloS one - 1 Jan 2012

Wong Patrick C M, Chandrasekaran Bharath, Zheng Jing

Abstract excerpt

The ASPM and MCPH1 genes have been implicated in the adaptive evolution of the human brain [Mekel-Bobrov N. et al., 2005. Ongoing adaptive evolution of ASPM, a brain size determinant in homo sapiens. Science 309; Evans P.D. et al., 2005. Microcephalin, a gene regulating brain size, continues to e...

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Source

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Identifiers

PMID: 22529908
DOI: 10.1371/journal.pone.0034243
PMCID: PMC3328485

Genes

ASPM
MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22529908-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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The derived allele of ASPM is associated with lexical tone perception.PMID 22529908Read ↗

Tone and genes: New cross-linguistic data and methods support the weak negative effect of the "derived" allele of ASPM on tone, but not of Microcephalin.Semantic proximity Read ↗

The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence.Semantic proximity Read ↗

Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".Semantic proximity Read ↗

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.Semantic proximity Read ↗

A Bayesian phylogenetic approach to estimating the stability of linguistic features and the genetic biasing of tone.Semantic proximity Read ↗

The spread of alphabetical writing may have favored the latest variant of the ASPM gene.Semantic proximity Read ↗

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.Semantic proximity Read ↗

Normal variants of Microcephalin and ASPM do not account for brain size variability.Semantic proximity Read ↗

Are languages really independent from genes? If not, what would a genetic bias affecting language diversity look like?Semantic proximity Read ↗

Comment on papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM.Semantic proximity Read ↗

Genome-wide investigation of prosody perception: Shared genetic influences between speech rhythm, musical rhythm, and reading traits.Semantic proximity Read ↗

A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performance.Semantic proximity Read ↗

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