Article
Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells.
The Journal of biological chemistry - 1 Jun 2012
Liu Xijun, Liu Dan, Qian Dongmeng, Dai Jenny, An Yi, Jiang Shaoyan, Stanley Bruce, Yang Jinming, Wang Bin, Liu Xinyuan, Liu David X
Abstract excerpt
Nucleophosmin (NPM1/B23) and the activating transcription factor 5 (ATF5) are both known to subject to cell type-dependent regulation. NPM1 is expressed weakly in hepatocytes and highly expressed in hepatocellular carcinomas (HCC) with a clear correlation between enhanced NPM1 expression and increased tumor grading and poor prognosis, whereas in contrast, ATF5 is expressed abundantly in hepatocytes and...
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