Article
Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes.
Autoimmunity - 1 Jun 2013
Andersen Mette K, Härkönen Taina, Forsblom Carol, Groop Per-Henrik, Knip Mikael, Tuomi Tiinamaija
Abstract excerpt
BACKGROUND AND AIMS: Patients with type 1 diabetes have antibodies to ZnT8 protein is encoded by SLC30A8. The C-allele of the R325 W variant in SLC30A8 is associated with type 2 diabetes and reduced beta-cell function in non-diabetic subjects. Our aim was to assess the prevalence of ZnT8 autoantibodies (ZnT8A) in patients with adult-onset diabetes, and to characterize associations between ZnT8A and phenotype, as...
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