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Article

Regulatory role of β-arrestin-2 in cholesterol processing in cystic fibrosis epithelial cells.

Journal of lipid research - 1 Jul 2012

Manson Mary E, Corey Deborah A, Bederman Ilya, Burgess James D, Kelley Thomas J

Abstract excerpt

Cystic fibrosis (CF) cells exhibit an increase in the protein expression of β-arrestin-2 (βarr2) coincident with perinuclear accumulation of free cholesterol. Arrestins are proteins that both serve as broad signaling regulators and contribute to G-protein coupled receptor internalization after agonist stimulation. The hypothesis of this study is that βarr2 is an important component in the mechanisms leading to...

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Identifiers

PMID: 22523395
DOI: 10.1194/jlr.M021972
PMCID: PMC3371238

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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