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Article

An image analysis method to quantify CFTR subcellular localization.

Molecular and cellular probes - 1 Aug 2014

Pizzo Lucilla, Fariello María Inés, Lepanto Paola, Aguilar Pablo S, Kierbel Arlinet

Abstract excerpt

Aberrant protein subcellular localization caused by mutation is a prominent feature of many human diseases. In Cystic Fibrosis (CF), a recessive lethal disorder that results from dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the most common mutation is a deletion of phenylalanine-508 (pF508del). Such mutation produces a misfolded protein that fails to reach the cell surface. To...

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Source

Identifiers

PMID: 24561544
DOI: 10.1016/j.mcp.2014.02.004

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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