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Article

Neuronal D-serine regulates dendritic architecture in the somatosensory cortex.

Neuroscience letters - 31 May 2012

Balu Darrick T, Coyle Joseph T

Abstract excerpt

D-Serine, which is synthesized by the enzyme serine racemase (SR), is a co-agonist at the N-methyl-D-aspartate receptor (NMDAR). In an animal model of NMDAR hypofunction, the constitutive SR knockout (SR-/-) mouse, pyramidal neurons in primary somatosensory cortex (S1) have reductions in the complexity, total length, and spine density of apical and basal dendrites. We wondered whether the dendritic pathology...

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Identifiers

PMID: 22521586
DOI: 10.1016/j.neulet.2012.04.020
PMCID: PMC3400345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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